Promethease reddit Hi I ran my 23andme raw data through genetic genie and the results came back and said I had a homozygous brca1 mutation. Promethease isnt using any of these studies to claim anything. I do plan on consulting my GP, but I wanted to see in the meantime if anybody else here (perhaps a clinical geneticist) has experience with (mis)calls for this SNP from NGS data. Terms & Policies. Members Online Question about rs1801181 - Diagnosed with Ehlers Danlos Syndrome Hey guys, I'm looking for a DNA test that provides me with health related information and not particularly about ancestry data (although that wouldn't hurt). How accurate would you say Promethease is as a I'm going through my husband's promethease data, and several of his highest-magnitude callouts are SNPs that impact HLA-B27 syndromes: rs13202464(A;G) rs116488202(C;T) Hi. When you uploaded it to Promethease did you also upload any other tests like Ancestry or 23andme. 7. Some of the details of the items say it occurs in people of "European descent" etc. r/promethease: A place for discussing Promethease, a report about your DNA based on the scientific literature cited in SNPedia. Promethease is only $12 but it's a one-time cost and you can keep running reports every so often as the science advances. On the T1, RA, and glaucoma risks, I'd make sure you know what symptoms you're looking for (excessive thirst, losing weight, eyesight changes, urinating frequently for diabetes. rs713993050 II Adrenoleukodystrophy Quoting the Promethease author's post in a closed Facebook group for Dante and Nebula: I'm the author of Promethease, and I now have a new thing which is designed from scratch for WGS (& WES). very little of the genome was actually surveyed), it can also mean that the person isn't carrying a known, "nasty" genotype such as one often leading to an unwanted medical condition; in other words, having a report with no Hello! Can anyone help me understand whether I can determine if I have a COMT mutation through my Promethease report? I am able to pull up some Your Promethease report should have shown that CHEK2 mutation, which is known as rs555607708 to most of the world but is named i4000462 by 23andMe. The new report (since they were bought by the Israeli company) Promethease is by far the best third-party data analysis tool, but there are many others out there to choose from. It is more of an educational tool than a health driven tool. The Promethease report you provided has four genetic variants related to EDS, two variants (rs42524 and rs1054480) associated with EDS, one variant (rs1801181) being investigated for its association with EDS, and one variant (rs587779540) with no known association. Can I do that without paying ? Or pay a reduced price ? My old report supposedly is in there, but downloading the report, it is empty. It's early and I'm looking for early adopters. I recently purchased a full genome sequence from sequencing. The problem is that we know these databases are wrong ~25% of the time. Instead, this company focuses on analyzing genetic markers in uploaded raw DNA data and providing detailed Promethease is a low-cost DNA analysis service that creates a report using the raw data you get from a genetic testing company. This is a welcoming place for those affected (or those simply wanting to learn more) to ask questions, share successes and Where did the Promethease reports go? When I went to "Reports" today, all I see is a blank page, so where are my previously Get app Get the Reddit app Log In Log in to Reddit. Also its an Isreali company with in itself is kinda sketchy. Expand user menu Open settings menu. Apparently it's pretty rare with a frequency of My wife and I both have all the same things showing for MTHFR. I do know that accuracy is not perfect with these tests, but I'm looking for the most reliable one. Or check it out in the app stores The following are my results from Promethease. 16 votes, 12 comments. On the SNPedia page for Ankylosing Spondylitis it mentions HLA-B27 is important, but in Promethease if you click on that medical condition the HLA-B27 SNPs don't even come up and I could only find them under the topic of HLA, but even there it doesn't even Being pure vegan is hard, but I try as best I can. It is not meant to be a post-peer review tool of those same studies. The two main ones being: rs1801131(A;C) Possibly impaired folate metabolism - MTHFR rs1801131 (C) or MTHFR A1298C Shortly after making it, I purchased a report from Promethease, which definitely seems more digestible than what I had been doing prior. Due to financial reasons, I am currently off my methylphenidate Promethease on the other hand is just a long list of mutually inconsistent reports on weak effect SNPs. On a YouTube video I just watched(the video itself it’s about 5 yrs old) showed medications, but I just did my report and it doesn’t show it. Although this can mean the raw data isn't very comprehensive (i. If you want to go deeper and find your terminal SNP, there are tests for that. bam files and that would require a huge investment of time. I just re-ran my same DNA file to get updated reports. Anything above magnitude 3 might be worth paying attention to. There are many types of ehlers-danlos and some of them cannot be identified by genetic testing but I was wondering if I actually do have one of the types that can be genetically identified. 5 times more likelihood of suffering from X” comes from a group study where a thousand people get sequenced and rare variation A is more common in people with X. Although I haven’t seen FMF reports since they did an update. A place for discussing Promethease, Get app Get the Reddit app Log In Log in to Reddit. I had never heard of it before, it didn’t come on my own either way, I tried to look again at my own report and no matter what I am putting in it’s not coming up in my report. In Promethease, he has multiple high risk alerts for strokes, clotting disorders and t2d. So then I uploaded the same raw data on promethease and it did not say I had any brca genetic mutations at all. Members Online Romano ward Long Qt syndrome Ok so I used WGSE (WGS Extract) to take my CRAM file and turn it into a file that would be accepted by promethease and genetic genie etc. The rules of 8. By the way, many Promethease reports have no genotypes of magnitude higher than 4. Somebody mentioned Promethease to me but I have just taken a look and there is some controversy as apparently they "sold out" to the genealogy company myheritage. Get app Get the Reddit app Log In Log in to Reddit. com (Dante had not shared data as of July 12, 2019) June 29, 2019 - ordered hard drive with BAM and FASTQ files (Dante had not shipped data as of July 12, 2019) 11 votes, 12 comments. r/promethease. Reddit users have expressed serious concerns about the validity of Promethease’s commitments to privacy. I know it's pretty common to get a lot of bad results, but what freaked me out most was a 3. I've joined promethease, and used the search term 'Ehlers' I've come up with about 15 RS listings which are listed as pathogenic for EDS. codegen. 4x risk of thrombosis (magnitude 4. Or check it out in the I have the rs6323 GG as well & from what I understand, producing more MAOA makes you more prone to ADHD & depression. Because of the lack of placebo response, you might want to check to see if you are also resistant to anti-depressants (I don't know if this is related but came up overwhelmingly on my promethease & wondered if they were correlated). They both take you to a blank wiki. It uploads because they do give you the raw data in a way that’s TECHNICALLY compatible with promethease, in the promethease can read 2 bases for each allele of each SNP, but it’s incompatible because of these formatting (I think that’s an appropriate word?) issues. There is reason to believe that I have Landau-Kleffner Syndrome, so I would like to get my whole genome sequenced if possible, what are my options? That’s what promethease said with a note it might be more serious with another genes involvement. So, any ideas what is happening!? Here is the stack : Traceback (most recent call last): Found out from Promethease that this indicates Lynch syndrome (due to a faulty MSH2 gene). bam and it posted a message that the file format was not supported. g. So I'm 40 and found and my mother has BC when she was 61, caught very early, still alive and kicking 16 years later. I never eat meat or fish. Promethease will report on hundreds or thousands of snp’s, FMF only reports on a limited number of snp’s for which it has a decent body of info on. 8K subscribers in the promethease community. I didn't get anything outlandish so I'm not really worried about false Promethease If you choose not to create an account. Land. This lead down a rabbit hole on how to create small . 1 being the highest I could go). Anything at 3 or lower are mostly curiosities. I have done both of those and have several anxiety inducing possible miscalls that I hope the full genome sequencing will confirm or exclude for me. . Members Online problem with uploading two tests. Then again, it In 2015 I used Promethease. If you have a YDNA test at FTDNA you get your Haplogroup estimation provided along with your matches. My DNA as interpreted by Genomelink predicts I have a preference with carbs than protein, because that is what my body needs. In other words, it means that SNP is normal and you likely do not carry any CYP2D6*3 alleles. Gotten a The conversation about Promethease on Reddit . June 28, 2019 - requested sync of data with sequencing. But i don't understand if Promethease will read my VCF or BAM But Tellmegen info is correct. can also check sry and ar genes plus there is list of conditions on the right you can scroll through. I have this gene variant also and struggle with severe anxiety my whole life. Or check it out in the app stores     TOPICS. Genes linked to Autism Spectrum Conditions(ASC) There was a significant association between rs2268493 in OXTR and AS. A place for discussing Promethease, a report about your DNA based on the Which DNA test is best to upload to Promethease of 23andMe, Ancestry, and MyHeritage? I already uploaded FTDNA in 2018, but now I intend to upload another test and want to have as much useful information about my DNA as possible, and I've done those four tests. I'm hoping to also put the full imputed genome from DNA Land into promethease, but figured it would be good to have a separate I was diagnosed with Ehlers-Danlos syndrome years ago and recently used Promethease as well. Is this a thing to watch or a thing to go check?? In order to better sort data Promethease has "magnitude" as an indicator. Note that this particular mutation is linked to a somewhat more moderate (~2-5 perhaps) increase in risk for breast cancer than are the more pathogenic BRCA1 and BRCA2 mutations, but does also have some other I recently took a look at my father’s Promothease report and noted he has the Warrior Gene (G,G). Log In / Sign Up; Advertise on Reddit; Shop Collectible Avatars; Get the Reddit app Scan this QR code to download the app now. 7K subscribers in the promethease community. Members Online Stressing out about Schizophrenia after looking up my DNA results I recently got my results and from what I'm reading nothing is too alarming or out of the ordinary from what I expected, aside from the glaring "gs122 7x increased risk for baldness" which is the first gene that appears on my list! My mother got terribly confused trying to figure out her Ankylosing Spondylitis risk in her Promethease report. More posts you may like r/promethease. vcf files from . I know this is super old, so not sure if you've learned anything else, but I also had rs35705950 in my report. On my main page, it shows mostly the "bad repute" items and most of them are a bit concerning. So I plugged my data into Promethease. I’m now in the process of doing a Whole Genome sequence as this is Promethease report is less interesting without raw data, too. Some users found that their genetic information had You pay promethease a little bit of money and they generate a report based on information in SNPedia. 8. For example thats how they transfer all of their data from Promethease to MyHeritage after the company acquisition. But there have been several in the history of this forum that turned out a false positive for this disease. yo-whatupmofo • Reddit . It shows a lot more information than 23andMe with a lot more junk. Would this mean I have a half mutation or what? I tried recently to upload my . I've seen that AncestryDNA and Promethease are both fairly accurate. The expert said it isn’t a straightforward Disease like that and full gene testing would need to be done which I didn’t do. Will Promethease tell me if I have MTHFR, COMT, etc? I just ordered the basic $99 version of 23 and Me and I was hoping to take the data once it's generated and find out what genetic mutations I may have I uploaded my data (23andme v4) in 2017, and would like to get an updated report. I filtered the report to find the genes that I had previously read are associated with my disorders. every G is paired with a C, and deciding whether to refer to a position as G or C is a little messy), but that couldn't turn your raw data's I just ran a promethease report hoping to find some info on meds recommended for anxiety/depression. My raw data is the same as when I was first uploaded it, but all of a sudden this is appearing at the top of my Promethease results. com primarily for CFTR related issues, but I'm lost when looking at the Genome Explorer 🤔🧐 do I have to re-upload all this to promethease to understand it, or can someone break down the basics for me? Get app Get the Reddit app Log In Log in to Reddit. Hi, I got my Promethease report with my AncestryDNA data. I'd go with the promethease report. SNPedia says to post questions here. eu is a decent free alternative to Promethease that gives you much of the same information. It's isn't the most pretty or user friendly but it does a reasonable job for the price. Promethease combines results from heaps of studies around the world. On those long flights, go for an aspirin or two, even with the impaired NSAIDs, IMO. comments sorted by Best Top New Controversial Q&A Add a Comment. I think it's important to note that there will be conflicts detected, but these conflicts should be listed by promethease. A subreddit for Etsy sellers on Reddit to collaborate and discuss techniques and experiences selling their products and building their stores. you can just look at the raw data and see if there is a y chromosome to confirm. i might be able to give more insight if i had more of your symptoms Note that this file used to work, and I had a report from Promethease last year. A place for discussing Promethease, a report about your DNA based on the scientific literature cited in SNPedia. But if you are looking for something specific, it may give you more information. Members Online Need help. I wish to make analyze my DNA for (rare diseases), with Nebula Genomics (WGS 100x). Have you taken the tutorial, and do you have questions about it? Please do so, and also read the /LearnMore pages because they should help you understand genetics a bit better before you jump to conclusions, and that's pretty essential to understanding any report about your DNA. that's how some intersex people discover they're not XX female. I'm also going to include markers associated with ADHD as I'm interested in learning about the links between them. So it's good to hear from an AA's perspective. I created my Promethease account and exported my 23andme data. I dont care what you have to say about promethease. Hi! I am a 27-year-old male with ADHD and generalized anxiety. One of the pages in the promethease report you can download shows a looong list of conditions, and there are red and green bars next to each that show your relative risk based on all of the SNPs related to each condition and whether each increases or decreases your risk. Reply reply Top 8% Rank by size . Press J to jump to the feed. I have used AncestryDNA, 23andMe & then CircleDNA to cross confirm this & dug into the literature in Promethease and scoured the web for the few published studies. Multiple haplotypes that include this SNP (rs2268493-rs2254298, rs2268490-rs2268493-rs2254298, rs2268493-rs2254298-rs53576, rs237885-rs2268490-rs2268493-rs2254298, rs2268490-rs2268493-rs2254298-rs53576) were also associated with That has become a life motto for me Anyway, I got the raw data from 23andMe and put it in Promethease and DNA. That individual SNPs don't matter one at the time in diseases such as Crohn's (or any other common disease for that matter) I happened to come across my promethease results 4 years after my initial Raw data was uploaded. 1K subscribers in the promethease community. I'm going to a genetic counselor in a few weeks to get tested again, but I want to know if I can trust my Promethease results for the most part. 10 votes, 11 comments. It is questionable. In addition, Promethease is a "look up table" that looks into public databases to see if there is any information about the meaning of the variant. FMF gives more discussion, Promethease gives topical highlights and links to studies, etc. I think it can make a difference likely in combination with other genetic variants because as has already been stated, it is a common variant so it can't just be this variant alone causing significant issues. e. 1, with 4. I've tried responding to the Processing Delay emails, and going to the Help/Contact section of Promethease. Any site that allows file uploads might include a feature for law enforcement to search for matches. I could relate to your animal snack comments; I didn't like beheading animal crackers at all! Promethease should call two genosets for CYP2D6, just use those. I had two of my female friends plug dna data into promethease and we all share this gene. I have an appointment tomorrow to discuss this with my PCP after my rheumatologist recommended following up with him. I then decided to poke around in my raw dna data and found rs1805086 and it says C/T. but I am of Asian ethnicity with no European traces. MH who bought their main source of data called "SNPpedia" and censored some of the data in that database reducing the types of reports they can be made. Or check it out in the app stores A place for discussing Promethease, a report about your DNA based on the scientific literature cited in SNPedia. Can someone explain my SNP to me? It reads: s909525(G;G) Perhaps MAOA 3 repeats: Warrior Gene?People with this SNP may also GEDMatch, Promethease, and other sites do not test your DNA but they do allow you to upload a file from a testing company for additional analysis, matching, etc. I’m perturbed. Oh - and please do up-vote if you see this. This is a support sub for those with Ehlers-Danlos syndrome (all types) and HSD—diagnosed or waiting to be diagnosed. It contains information on thousands of SNPs, but you can filter it to find the ones that Today I’m showing you how to make the most out of your Promethease report, by giving you suggestions on how to filter and sort it to produce the easiest, most digestible report. In a Promethease report, such a genotype will often be 'framed' in green, since it's harmless. 26 votes, 11 comments. A result that says “gene variation A gives you 1. Since you say you have Rs35742686(I;I) on Promethease, that means I can ignore orientation issues, so that corresponds to the Rs35742686(A;A) entry on the Rs35742686 page. I’ll put it simply - if you have to go on a bulletin Promethease links to a bunch of studies, many of which you will have absolutely no interest in. reReddit: Top posts of January 6, 2021. My dad has all three of them so I felt a little shocked by its accuracy. Promethease is a good tool if you know what you're doing with it. I've been looking through my genes and the following are those I have that are associated with Autism. WGSE noted 47 chromosomes and did show the Y chromosome and then when I loaded the data to promethease I got this genoset (gs261). It seems this reddit is so controlled by pro-promethease people, that it's almost impossible to write anything negative about them without getting kicked to the end of the stack. So I downloaded my raw data from myheritage and uploaded it to promethease and found that I'm a carrier of this gene : rs4307059 (T;T) (magnitude : 3 ) The promethease report seems to be legitimate, found out I may develop type 2 diabetes,prostate cancer,baldness. And promethease is capable of reporting on all of them, but we can only tell you about the ones that you were tested for. Log In / Sign Up; Advertise on Reddit; Shop Collectible Avatars; A place for discussing Promethease, a report about your DNA based on the scientific literature cited in SNPedia. A place for discussing Promethease, a report about your DNA based on the I've now had access to Promethease results for many members of my family, along with a couple of friends and we were all AG. I have been working in the genomics and diagnostics industry for over 25 years and in my opinion the Promethease service is simply unethical. I've done 23andMe v4 and AncestryDNA v2d, but they don't contain a lot of data about GRIN2A. Internet Culture (Viral) Amazing; (harmless). Go figure. Get the Reddit app Scan this QR code to download the app now. Im just saying you're complaining about something promethease was never meant or claim to do. I know very little about this whole topic and so it makes me nervous to see positive JAK2 V617F. 5-4. I printed out a copy of everything in my report above a magnitude of 3 and brought it to my PCP when I went for a regular check up. If you decide to create the account they reserve the rights to share your data with their partners. I don't want to go to my doctor looking like a hypochondriac if these are insignificant and the number of them, for different genes, makes me think they probably are actually miscalls. Promethease is a DNA data analysis and literature retrieval system that does not offer DNA testing services. It’s just fucked on promethease. Regardless of all the well meaning explanations of magnitude - ok, I guess ultimately they point to the same thing. Each company tests different snps, and most snps are not tested by any company. Hi, I'm totally new to all of this, but I have some health issues and some bodily features which strongly suggest one of the EDS variants. Maybe cariaso could have some insight? Mismatches do sometimes appear to happen when SNPedia and your data provider refer to opposite strands of DNA (e. As long as you enter into the agreement knowing that you might find out less-than-stellar information, and do your research around genes, you'll be fine. No files > 4GB are supported. r/promethease: A place for discussing Promethease, a report about your DNA based on the scientific literature cited in SNPedia. I've seen it go both ways. the results indicate multiple SPNs with "higher risk" for developing the MPN. Log In / Sign Up; Advertise on Reddit; Shop Collectible Avatars; Get the Reddit app Scan this QR code to download the You can't use Promethease to analyse a complex disease like Crohn's. I tested with Ancestry and according to Promethease it was indeed the v2c version. I see under “Topic” there’s a section called “haplogroups” a section called “mtDNA haplogroups” and one called “mitochondrial haplogroups” but Hmm that looks like a real bug to me, but I don't know promethease that well. Reddit iOS Reddit Android Rereddit Best Communities Communities About Reddit Blog Careers Press. I very much doubt that Promethease reports would provide any haplogroup at all. Instead of fish oil I take algae omega. If you find anything worth digging into, make sure that SNP isn't on the conflict list and always reference it against nebula's information to ensure accuracy using this method. I have now found a lump and the breast clinic asked me if I have the BRCA gene but I had no idea then realised I had the 23andMe data parsed through promethease so I was hoping someone could tell me more about these Snps that come up in Red when I check This is the right answer. Also just know that Ancestry seems to give a lot of weird misscalls with Promethease, so if some rare genetic disorder/disease shows up just know it may just be I've been reading about this "hercules gene" and how it could increase muscle bulk due to a myostatin deficiency. HCM patients are very amused to find their mutation on promethease. Its just telling you those studies are there. kvgsj mnmus cdgusyy zxghp jec cpbs urby hoiwrr dhtljz uywrlup